Gray, Nathanael: search on Z-Library

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1

Kinase inhibitors: the road ahead

Ferguson, Fleur M., Gray, Nathanael S.

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 1.47 MB

english, 2018

2

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

Zhou, Wen, Whiteley, Aaron T., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Mekalanos, John J., Kranzusch, Philip J.

Journal:

Year:

2018

Language:

english

File:

PDF, 6.60 MB

english, 2018

3

When Kinases Meet PROTACs

Tan, Li, Gray, Nathanael S.

Journal:

Chinese Journal of Chemistry

Year:

2018

Language:

english

File:

PDF, 1.39 MB

english, 2018

4

Small Molecules that Induce Cardiomyogenesis in Embryonic Stem Cells

Wu, Xu, Ding, Sheng, Ding, Qiang, Gray, Nathanael S., Schultz, Peter G.

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 240 KB

english, 2004

5

Discovery of a potent dual ALK and EGFR T790M inhibitor

Jang, Jaebong, Son, Jung Beom, To, Ciric, Bahcall, Magda, Kim, So Young, Kang, Seock Yong, Mushajiang, Mierzhati, Lee, Younho, Jänne, Pasi A., Choi, Hwan Geun, Gray, Nathanael S.

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 3.34 MB

english, 2017

6

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Williams, Charles A. C., Gray, Nathanael S., Findlay, Greg M.

Journal:

Journal of Visualized Experiments

Year:

2017

Language:

english

File:

PDF, 559 KB

english, 2017

7

Repurposing of Kinase Inhibitors for Treatment of COVID-19

Weisberg, Ellen, Parent, Alexander, Yang, Priscilla L., Sattler, Martin, Liu, Qingsong, Liu, Qingwang, Wang, Jinhua, Meng, Chengcheng, Buhrlage, Sara J., Gray, Nathanael, Griffin, James D.

Journal:

Pharmaceutical Research

Year:

2020

File:

PDF, 1.98 MB

2020

8

Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors

Yongmun Choi, Farisa Syeda, John R. Walker, Patrick J. Finerty Jr., Dominic Cuerrier, Amy Wojciechowski, Qingsong Liu, Sirano Dhe-Paganon, Nathanael S. Gray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 307 KB

english, 2009

9

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

Taipale, Mikko, Krykbaeva, Irina, Whitesell, Luke, Santagata, Sandro, Zhang, Jianming, Liu, Qingsong, Gray, Nathanael S, Lindquist, Susan

Journal:

Nature Biotechnology

Year:

2013

Language:

english

File:

PDF, 1.44 MB

english, 2013

10

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

Faust, Tyler B., Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.

Journal:

Nature Chemical Biology

Year:

2020

File:

PDF, 3.40 MB

2020

11

A Combinatorial Scaffold Approach toward Kinase-Directed Heterocycle Libraries

Ding, Sheng, Gray, Nathanael S., Wu, Xu, Ding, Qiang, Schultz, Peter G.

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 83 KB

english, 2002

12

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-Like receptor agonists

Vollmer, Stefan, Strickson, Sam, Zhang, Tinghu, Gray, Nathanael, Lee, Katherine, Rao, Vikram, Cohen, Philip

Journal:

Biochemical Journal

Year:

2017

Language:

english

File:

PDF, 573 KB

english, 2017

13

A Structure-Guided Approach to Creating Covalent FGFR Inhibitors

Wenjun Zhou, Wooyoung Hur, Ultan McDermott, Amit Dutt, Wa Xian, Scott B. Ficarro, Jianming Zhang, Sreenath V. Sharma, Joan Brugge, Matthew Meyerson, Jeffrey Settleman, Nathanael S. Gray

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

14

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

Chaikuad, Apirat, M C Tacconi, Eliana, Zimmer, Jutta, Liang, Yanke, Gray, Nathanael S, Tarsounas, Madalena, Knapp, Stefan

Journal:

Nature Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.50 MB

english, 2014

15

Light-induced control of protein destruction by opto-PROTAC

Liu, Jing, Chen, He, Ma, Leina, He, Zhixiang, Wang, Dong, Liu, Yi, Lin, Qian, Zhang, Tinghu, Gray, Nathanael, Kaniskan, H. Ãmit, Jin, Jian, Wei, Wenyi

Journal:

Science Advances

Year:

2020

Language:

english

File:

PDF, 4.55 MB

english, 2020

16

A Concise and Traceless Linker Strategy toward Combinatorial Libraries of 2,6,9-Substituted Purines

Ding, Sheng, Gray, Nathanael S., Ding, Qiang, Schultz, Peter G.

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 68 KB

english, 2001

17

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

Morita, Ken, He, Shuning, Nowak, RadosÅaw P., Wang, Jinhua, Zimmerman, Mark W., Fu, Cong, Durbin, Adam D., Martel, Megan W., Prutsch, Nicole, Gray, Nathanael S., Fischer, Eric S., Look, A. Thomas

Journal:

Year:

2020

File:

PDF, 7.18 MB

2020

18

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

Jänne, Pasi A., Gray, Nathanael, Settleman, Jeff

Journal:

Nature Reviews Drug Discovery

Year:

2009

Language:

english

File:

PDF, 755 KB

english, 2009

19

Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor

Jang, Jaebong, Son, Jieun, Park, Eunyoung, Kosaka, Takayuki, Saxon, Jamie A., De Clercq, Dries, Choi, Hwan Geun, Tanizaki, Junko, Eck, Michael J., Jänne, Pasi A., Gray, Nathanael Schiander

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 1.31 MB

english, 2018

20

mTOR mediated anti-cancer drug discovery

Qingsong Liu, Carson Thoreen, Jinhua Wang, David Sabatini, Nathanael S. Gray

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2009

Language:

english

File:

PDF, 467 KB

english, 2009

21

Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum

Leonie Harmse, Robyn van Zyl, Nathanael Gray, Peter Schultz, Sophie Leclerc, Laurent Meijer, Christian Doerig, Ivan Havlik

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 320 KB

english, 2001

22

SnapShot: Kinase Inhibitors I

Wang, Jinhua, Gray, Nathanael S.

Journal:

Year:

2015

Language:

english

File:

PDF, 58 KB

english, 2015

23

mRNA expression profile of a human cancer cell line in response to a phytochemical extract with antioxidant properties

Gohil, Kishorchandra, Packer, Lester, Gray, Nathanael, Rosania, Gustavo Rafael, Moy, Ronald K., Maguire, John, Schultz, Peter G.

Journal:

Nature Genetics

Year:

1999

Language:

english

File:

PDF, 90 KB

english, 1999

24

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1

Deng, Xianming, Yang, Qingkai, Kwiatkowski, Nicholas, Sim, Taebo, McDermott, Ultan, Settleman, Jeffrey E., Lee, Jiing-Dwan, Gray, Nathanael S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.10 MB

english, 2011

25

The ins and outs of selective kinase inhibitor development

Müller, Susanne, Chaikuad, Apirat, Gray, Nathanael S, Knapp, Stefan

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 940 KB

english, 2015

26

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival

Wang, Yubao, Begley, Michael, Li, Qing, Huang, Hai-Tsang, Lako, Ana, Eck, Michael J., Gray, Nathanael S., Mitchison, Timothy J., Cantley, Lewis C., Zhao, Jean J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.26 MB

english, 2016

27

Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13

Liu, Yao, Hao, Mingfeng, Leggett, Alan, Gao, Yang, Ficarro, Scott B, Che, Jianwei, He, Zhixiang, Olson, Calla, Marto, Jarrod A., Kwiatkowski, nicholas, Zhang, Tinghu, Gray, Nathanael S

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.20 MB

2020

28

Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II

Guobao Zhang, Pingda Ren, Nathanael S. Gray, Taebo Sim, Xia Wang, Yi Liu, Jianwei Che, Weitong Dong, Shin-Shay Tian, Mark L. Sandberg, Tracy A. Spalding, Russell Romeo, Maya Iskandar, Zhiliang Wang, H

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 393 KB

english, 2009

29

Synthesis and Target Identification of Hymenialdisine Analogs

Yongqin Wan, Wooyoung Hur, Charles Y. Cho, Yi Liu, Francisco J. Adrian, Olivier Lozach, Stéphane Bach, Thomas Mayer, Doriano Fabbro, Laurent Meijer, Nathanael S. Gray

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

30

Small molecule modulators of antioxidant response pathway

Wooyoung Hur, Nathanael S Gray

Journal:

Current Opinion in Chemical Biology

Year:

2011

Language:

english

File:

PDF, 352 KB

english, 2011

31

Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 – 2011)

Deng, Xianming, Choi, Hwan Geun, Buhrlage, Sara J., Gray, Nathanael S.

Journal:

Expert Opinion on Therapeutic Patents

Year:

2012

Language:

english

File:

PDF, 537 KB

english, 2012

32

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors

Deng, Xianming, Wang, Jinhua, Zhang, Jianming, Sim, Taebo, Kim, Nam Doo, Sasaki, Takaaki, Luther, William, George, Rani E., Jänne, Pasi A., Gray, Nathanael S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.13 MB

english, 2011

33

A Structure-Based Library Approach to Kinase Inhibitors

Norman, Thea C., Gray, Nathanael S., Koh, John T., Schultz, Peter G.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 47 KB

english, 1996

34

Solid-Phase Synthesis of 2,3,5-Trisubstituted Indoles

Wu, Tom Y. H., Ding, Sheng, Gray, Nathanael S., Schultz, Peter G.

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 91 KB

english, 2001

35

TSC1 involvement in bladder cancer: diverse effects and therapeutic implications

Guo, Yanan, Chekaluk, Yvonne, Zhang, Jianming, Du, Jinyan, Gray, Nathanael S, Wu, Chin-Lee, Kwiatkowski, David J

Journal:

The Journal of Pathology

Year:

2013

Language:

english

File:

PDF, 532 KB

english, 2013

36

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors

Kalan, Sampada, Amat, Ramon, Schachter, Miriam Merzel, Kwiatkowski, Nicholas, Abraham, Brian J., Liang, Yanke, Zhang, Tinghu, Olson, Calla M., Larochelle, Stéphane, Young, Richard A., Gray, Nathanael

Journal:

Year:

2017

Language:

english

File:

PDF, 4.48 MB

english, 2017

37

Interleukin-6 Secretion by Astrocytes Is Dynamically Regulated by PI3K-mTOR-Calcium Signaling

Codeluppi, Simone, Fernandez-Zafra, Teresa, Sandor, Katalin, Kjell, Jacob, Liu, Qingsong, Abrams, Mathew, Olson, Lars, Gray, Nathanael S., Svensson, Camilla I., Uhlén, Per, Di Giovanni, Simone

Journal:

Year:

2014

Language:

english

File:

PDF, 17.28 MB

english, 2014

38

A multi-targeted probe-based strategy to identify signaling vulnerabilities in cancers

Rao, Suman, Du, Guangyan, Hafner, Marc, Subramanian, Kartik, Sorger, Peter K., Gray, Nathanael S.

Journal:

Journal of Biological Chemistry

Year:

2019

Language:

english

File:

PDF, 2.33 MB

english, 2019

39

What It Takes to Improve a First-Generation Inhibitor to a Second- or Third-Generation Small Molecule

Rodon Ahnert, Jordi, Gray, Nathanael, Mok, Tony, Gainor, Justin

Journal:

American Society of Clinical Oncology Educational Book

Year:

2019

Language:

english

File:

PDF, 489 KB

english, 2019

40

Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold

Remillard, David, Buckley, Dennis L., Seo, Hyuk-Soo, Ferguson, Fleur M., Dhe-Paganon, Sirano, Bradner, James E., Gray, Nathanael S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 12.23 MB

english, 2019

41

Inhibition of the deubiquitinase USP10 induces degradation of SYK

Yang, Jing, Meng, Chengcheng, Weisberg, Ellen, Case, Abigail, Lamberto, Ilaria, Magin, Robert S., Adamia, Sophia, Wang, Jinhua, Gray, Nathanael, Liu, Suiyang, Stone, Richard, Sattler, Martin, Buhrlage

Journal:

British Journal of Cancer

Year:

2020

File:

PDF, 1.81 MB

2020

42

Discovery of Covalent MKK4/7 Dual Inhibitor

Jiang, Jie, Jiang, Baishan, He, Zhixiang, Ficarro, Scott B., Che, Jianwei, Marto, Jarrod A., Gao, Yang, Zhang, Tinghu, Gray, Nathanael S.

Journal:

Cell Chemical Biology

Year:

2020

File:

PDF, 2.85 MB

2020

43

A General Strategy for Creating “Inactive-Conformation” Abl Inhibitors

Barun Okram, Advait Nagle, Francisco J. Adrián, Christian Lee, Pingda Ren, Xia Wang, Taebo Sim, Yongping Xie, Xing Wang, Gang Xia, Glen Spraggon, Markus Warmuth, Yi Liu, Nathanael S. Gray

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 440 KB

english, 2006

44

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Azam, Mohammad, Seeliger, Markus A, Gray, Nathanael S, Kuriyan, John, Daley, George Q

Journal:

Nature Structural and Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.08 MB

english, 2008

45

An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit

Xianming Deng, Wenjun Zhou, Ellen Weisberg, Jinhua Wang, Jianming Zhang, Takaaki Sasaki, Erik Nelson, James D. Griffin, Pasi A. Jänne, Nathanael S. Gray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.01 MB

english, 2012

46

GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein

Clark, Margaret J., Miduturu, Chandra, Schmidt, Aaron G., Zhu, Xuling, Pitts, Jared D., Wang, Jinhua, Potisopon, Supanee, Zhang, Jianming, Wojciechowski, Amy, Hann Chu, Justin Jang, Gray, Nathanael S.

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.09 MB

english, 2016

47

Discovery of host-targeted covalent inhibitors of dengue virus

de Wispelaere, Mélissanne, Carocci, Margot, Liang, Yanke, Liu, Qingsong, Sun, Eileen, Vetter, Michael L., Wang, Jinhua, Gray, Nathanael S., Yang, Priscilla L.

Journal:

Antiviral Research

Year:

2017

Language:

english

File:

PDF, 6.56 MB

english, 2017

48

A Small-Molecule Inducer of the Antioxidant Response Element

Wooyoung Hur, Zheng Sun, Tao Jiang, Daniel E. Mason, Eric C. Peters, Donna D. Zhang, Hendrik Luesch, Peter G. Schultz, Nathanael S. Gray

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1.52 MB

english, 2010

49

10.1038/35030148

Shokat, Kevan M., Bishop, Anthony C., Ubersax, Jeffrey A., Petsch, Dejah T., Matheos, Dina P., Gray, Nathanael S., Blethrow, Justin, Shimizu, Eiji, Tsien, Joe Z., Schultz, Peter G., Rose, Mark D., Woo

Journal:

Year:

2000

Language:

english

File:

PDF, 416 KB

english, 2000

50

Brain Penetrant LRRK2 Inhibitor

Choi, Hwan Geun, Zhang, Jinwei, Deng, Xianming, Hatcher, John M., Patricelli, Matthew P., Zhao, Zheng, Alessi, Dario R., Gray, Nathanael S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.80 MB

english, 2012

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